- Statin therapy has a well-established role in the treatment of high cholesterol and reduction of cardiovascular disease risk.
- Generally, statin therapy is considered safe and has a side effect profile with a low incidence rate that is also reversible.
- Statin therapy in patients with increased cholesterol or existing cardiovascular disease has been reported to potentially contribute to diabetes mellitus (DM).
- Statin medications may cause an increase in blood sugar that can potentially lead to DM or similar signs and symptoms of DM.
- For secondary prevention of cardiovascular events, statin therapy has been established. However, when it comes to secondary prevention the risk-benefit of statin therapy is less clear.
There is a relatively decent amount of data that assesses the effects of statin therapy on the induction of type 2 diabetes mellitus (T2DM). In a retrospective cohort study, 265,414 patients aged 40-70 years of age were evaluated for statin-induced DM. In this study group, 17.9% of the patient were treated with statins. In the four years this study was conducted, there were 5,157 new cases of cardiovascular disease and 11,637 new DM diagnoses. The results showed that low-intensity statin therapy in which the patient was over 50% adherent was associated with an increased risk of DM in those with low or intermediate baseline CV risk. In patients with high CV risk, the same was not true and there was no association. In patients that started statin therapy with low CV risk, no CV protective benefit was observed. The researchers calculated the number needed to harm (NNH) for one patient treated with a low-intensity statin that was above 50% adherent as 40. In those with intermediate and high CV risk, the NNH was 50 and 200, respectively. This study concluded that low-dose statin therapy in those with high CV risk is beneficial, however may be detrimental to those with low CV risk.
A meta-analysis was performed to investigate the association of statins and DM further . The analysis identified studies in the Embase, Cochrane, and PubMed databases. In total there were 29 trials included in the analysis that consisted of 163,039 subjects. The analysis found that statin medications significantly increased the likelihood of patients developing DM by 12%. Based on the results of the study, it also seems as though higher intensity statin medications such as atorvastatin and rosuvastatin have higher associated risks of leading to DM than do low-intensity statins. Looking further into the drug information data according to Lexicomp, atorvastatin’s adverse events include endocrine & metabolic disorders such as DM. It is stated that the risk of this adverse event is up to 6% .
- Porath A, Arbelle JE, Fund N, Cohen A, Mosseri M. Statin Therapy: Diabetes Mellitus Risk and Cardiovascular Benefit in Primary Prevention. Isr Med Assoc J. 2018;20(8):480-485.
- Thakker D, Nair S, Pagada A, Jamdade V, Malik A. Statin use and the risk of developing diabetes: a network meta-analysis. Pharmacoepidemiol Drug Saf. 2016;25(10):1131-1149. doi:10.1002/pds.4020
- Atorvastatin Drug Information. In: Post TW, ed. UpToDate. Waltham, MA: UpToDate Inc.
Taking Care of Oneself
Student life is a penance. Here nothing is available at one trick of a magic wand instead for each and every single thing a student has to do a lot of effort. As the time passes by, the burden on the shoulders of the students is increasing. These days students have to go through a lot of situations for which they are not even ready yet but the competition level is so high that students are sacrificing their childhood in order to win that competition. Students these days are burdened with so many responsibilities where they get tangled between home and academics and hence, they remain neither good enough for home nor for school life. Even student life runs on some strategies and in lack of those strategies student life gets scattered. Students need to manage things in their student life by getting them organized from beginning to finishing. Earlier students didn’t have any support but today there are several supportive tools in the market like LMS portals and ERP for school which support the students up to that level where students are able to manage their studies by themselves. Among such a hectic schedule students will be able to perform well only when they will take care of themselves. Because learners are doing everything these days except taking care of themselves. A healthy lifestyle includes looking after physical, mental and emotional well-being. Students should be well aware about when the things are getting out of control and how to manage those uncontrolled things in academic life. And lastly students are able to cope up with their responsibilities while taking care of themselves. It is so because when things get adverse then it takes a toll on health.
To take care of health students need to change their careless routine because it is easy to give up sleep for studies but sleep is as necessary for the health as studies for the career and life. Sleep is very important for physical and mental health because the mind and body get recharged while one sleeps and for the students’ sleep is that medium through which information gets stored for the long term in memory and thus makes sleep an important ingredient for school life. For better sleep students should make a sleep routine when TV, mobile & all the distractions should be kept away, all the lights should be killed in the room and make a dark atmosphere which will help in sleep and relax. Students should keep a healthy routine of diet also where they should drink plenty of water, limit the junk food, eat fresh fruits and green vegetables which should be full of protein and nutrients. Students should take regular meals and should not skip this regular routine even for once due to any reason. Also, students need to take care of eating habits and should escape overeating. ERP for school takes care that students should get help and support from the school management in taking their care as LMS portals take care of online learning of the students. Students need to keep themselves healthy with the help of regular exercise to build a strong body and attentive mind which can contribute to the academic life of the students and give them a proper career. Students should take care of their physical and mental well being by maintaining the mood with the help of meditation and entertainment like by watching comedy and cartoon movies sometimes. As elucidated above students need to take an ample amount of sleep of 6-8 hours properly. It is necessary for the health of the students that they should keep talking to their dear ones. It is so because they are also humans and they need to express themselves to someone very dear to them, with whom they can share their stress and pressure and also their emotions about their personal lives, about their ambitions and efforts they are making about them to make those dreams come true. Talking to people makes mental status balanced and students become able to deal with the stress of winning and getting the benchmarks set by them. Students need to take a break when they need to and should never study continuously. A pause is necessary to relax the mind in order to retain the capacity to perform again.
Is There a Standard Dose of Kratom?
There is no one-dose-suits-all. Kratom is a unique herb that affects people differently based on their power of tolerance, metabolism, age, gender, body weight and size, and the way they take the herb.
Users report that kratom works stronger when taken on an empty stomach than when taken with food.
However, kratom softgels, capsules, or powder on an empty stomach does not suit everybody. So, despite experts advising you to take kratom the first thing in the morning, you shouldn’t, if it does not suit you.
Why take kratom the first thing in the morning?
Experts give this advice because kratom produces the most wonderful effect when you take it on an empty stomach in the morning. In this case, just a small dose can give a powerful effect.
Also, be careful where you buy your kratom from. If you felt sick after taking the herb, it could be that the product was stale or of poor quality. Search for “kratom near me” to find only licensed vendors who sell pure and high-quality kratom.
The trick to using kratom if it does not suit an empty stomach
Take kratom with a smoothie or citrus juice like lemon, orange, or grapefruit. Or you can take it with a few spoonfuls of your favorite cereals or a handful of nuts.
Take only a light meal.
If you take a heavy or complete meal with kratom, you won’t get the desired effects. The meal would dilute the concentration of alkaloids and their effects.
After 45-60 minutes, once the effect has set in, you can take your breakfast or meal.
A standard dose of kratom
It is seen that high-quality kratom powder in a dose of 1-3 grams is ideal to get enough energy to sail throughout the day.
The dose depends on kratom use and strain
Why do you wish to take kratom in Alaska?
This is an important question you must ask yourself before you take this Asian herb. Your dose and the choice of strain depend on the answer to this question.
Do you want kratom for energy or for reducing anxiety? Are you suffering from insomnia or want pain relief?
To go into the details, you must also consider how severe your problem is. Do you have severe pain or just mild body ache or stiffness? Are you into severe anxiety or depression or is it just the usual low mood?
All these factors play a role in the choice of strain and in fixing the dose.
Strains of kratom
- White strain is largely for energy, mood elevation, and euphoric feeling.
- Red strain is largely for pain relief, inducing sleep and relaxation, and calming the mind.
- Green strain is a bit milder than white and red ones and gives a balanced effect. Why not try Premium Green Malay Kratom Capsules and see how the green strain works on you?
- Gold strain is a hybrid strain that contains a mix of other strains, depending on the vendor’s choice.
Take kratom and see how it suits you. Then fix the dose as per your requirements and tolerance level.
What Signs Indicate That You May Have Diabetes?
Diabetes is a disease that affects the way your body metabolizes sugar. Insulin is a hormone that helps your body use sugar for energy, but the pancreas produces it. When you have diabetes, your body either does not produce enough insulin or cannot properly process sugar, causing sugar to build up in the bloodstream.
Diabetes is a severe disease that can lead to complications like heart disease and stroke if it is not treated correctly. Diabetes may be hard to detect because many people with the condition do not show any symptoms. If you are concerned about your risk of diabetes, read this entire article to know what signs indicate that you may have it.
What Are the Symptoms of Diabetes?
1. Unexplained Weight Loss or Gain (over about two weeks)
The first sign of type 2 diabetes is often weight loss and gain. Note that this does not mean that you instantly lose or gain weight, but that the change happens relatively briefly. This is because your body can no longer make insulin, which allows glucose to enter your cells. When glucose builds up in your bloodstream instead of entering your cells, it can cause many complications like sudden (over about two weeks) weight gain or loss.
2. Frequent Urination (sometimes at night)
Frequent urination is when excess sugar in your blood causes your kidneys to filter out more water than usual, leading to an imbalance of fluids in the body. The kidneys respond by increasing the amount of urine they produce and releasing it more frequently.
Other conditions besides diabetes may cause frequent urination. But if you have diabetes and frequent urination, you may have an increased risk of kidney disease and nerve damage to the feet (diabetic neuropathy).
3. Extreme Thirst – Especially in Hot Weather or After Exercise – which may lead to Dehydration
If you have diabetes, your body will have a tough time regulating the amount of sugar in your blood, which can cause high glucose and ketones levels, which can lead to Dehydration. If you experience extreme thirst, especially after exercise or in hot weather, it may be a symptom of diabetes.
4. Fatigue or Weakness
If you have diabetes, you may feel very tired or weak, and this is a common symptom of diabetes that high blood glucose levels can cause. High blood glucose levels can lead to Dehydration, which makes you feel tired.
5. Blurry Vision and Other Eye Problems
It is a common misconception that diabetes only affects the pancreas. While this organ does play a significant role in glucose metabolism, recent research has revealed that other organs and systems are also affected by diabetes.
One such example is the eye. Diabetes can cause blurred vision (diabetic retinopathy) and cataracts (diabetic cataracts). People with diabetes are also more likely to develop glaucoma, leading to blindness if left untreated.
6. Slow-Healing Sores or Infections that Don’t Heal Quickly
If you have any of the above symptoms, Use the below-given Apps to Manage your Diabetes.
Diabetes Management Apps
Diabetes management apps can help you manage your diabetes by providing information about the disease and its treatment. They also allow you to track your blood sugar levels and order your food intake and physical activity.
Most diabetes management apps include tools to track your glucose levels and adjust your treatment plan, and some also offer support groups, educational programs, and other helpful resources. Here are the must-have diabetes apps:
● Klinio – The Diabetes Management App
Klinio, the innovative diabetes management application, is customized diabetes and weight management, assistant. The application was intended for the individuals who battle with the way of life-threatening diseases, for example, hypertension, high sugar, cholesterol levels, weight, and so forth. It offers flexible schedules that align with the suggested day-to-day measures of sugar, cholesterol, and starches.
The application’s designers include a group of expert nutritionists who offer expert direction on diabetes on the board to hold your wellbeing under tight restraints. The app guarantees you the counting calories plan and, surprisingly, cuts down any additional load without being compelled to eat food sources you could do without.
Klinio diabetes management app offers.
- Detailed Meal Plans
- Comprehensive Grocery List
- Simplified Workouts for beginners
- Detailed Activity Log
- A detailed progress tracker
- User-Friendly App with tracking
● Chronometer – Calorie Counter
The Chronometer is a calorie counter app for people trying to have healthy meals. It allows you to track your daily caloric intake and keep track of your diet. A chronometer can also be used as a digital food scale.
Chronometer is easy to use, with a simple interface that makes it easy to enter foods into your daily log. You can select from over 6,000 food items in the database or add custom foods yourself.
MySugr is the first and only app that makes it easy to manage your diabetes. From blood glucose monitoring, meal planning, and calorie intake tracking to insulin dosage and blood pressure control, MySugr is here to help you in your daily fight against diabetes.
● Nike Training Club
The Nike Training Club app is designed to help you get fit and stay healthy. The app offers training programs that experts design and motivational tools and tips from real people. You can also connect with friends and family through the app to motivate you to train.
Nike Training Club App Features
- The Nike Training Club app has several features that make it stand out from other fitness apps:
- Personalized workouts based on your fitness level, goals, and preferences
Many apps and websites can help you manage your health, but Klinio is a leader in this area. As a nutritionist and diabetes management application, Klinio changes how you view food, your dietary patterns, and its effect on your general wellbeing. The application guides you into little viable strides towards accomplishing your term results. It resembles an aide, eliminating anything that way of life obstructions you face as you continue looking for a solid living – with attention to reasonable improvement.
Why You Should Try Skin Tightening Treatment
The skin is the most visible organ of the body, and it can give away our age, health, and lifestyle. Many people are self-conscious about their appearance and want to look their best. Luckily, skin tightening treatments exist to help us achieve this goal. These treatments use radiofrequency energy or intense pulsed light to heat the tissue beneath the skin’s surface, causing collagen fibers to contract. The result is a tighter, firmer appearance that can last for months or years. These treatments use laser energy or ultrasound to heat the skin, causing it to contract. This, in turn, stimulates the production of collagen—a key protein in the skin that helps keep it looking young and healthy. While results vary from person to person and treatment to treatment, many people report seeing significant improvements in their skin’s appearance after just a few sessions.
How to Find a Right Place for Skin Tightening Treatment
Skin tightening treatments can be done in many places. The best place to have this procedure done is at a specialized skin clinic such as Ambrosia Aesthetics, Mumbai. This facility has the right equipment and nurses to ensure the safety of the patient. In addition, they also have a medical staff that can give you advice on how to care for your skin after the treatment is done.
- One way to do so is by consulting with a dermatologist who can recommend the best location for the procedure.
- Do your research. read reviews and compare providers.
- Ask around. Talk to friends and family members who have had similar treatments and ask for their recommendations.
- Meet with potential providers in person. This will give you a chance to ask questions.
Why do you Need Skin Tightening Treatment?
As we age, our skin gradually becomes lax and less firm, resulting in wrinkles and an overall loss of elasticity. This is largely due to the decrease in the production of collagen and elastin, which are essential proteins that help keep skin looking young and healthy. While there are many ways to treat these signs of aging, such as plastic surgery or laser therapy, skin tightening treatments are a popular and non-invasive option.
Skin tightening is a treatment that uses a light ultrasound to tighten excess skin in the areas of your face, neck, arms, or hands. This process can also be used for other parts of the body as well. When you have loose skin, it can cause wrinkles and sag. The loose skin is tightened using the ultrasound and will help to make your skin firmer. A skin tightening treatmentis an important part of your skincare routine.
- It can help improve the appearance of your skin, reduce signs of aging, and smooth out wrinkles.
- It is a non-invasive procedure that relies on a variety of ingredients including radiofrequency energy, mild laser therapy, and other cutting-edge technologies to provide deep hydration and collagen stimulation.
- Skin tightening can help with wrinkles and acne scarring, but it is important to remember that you may need replacement surgery.
- It can help remove unwanted fat that has been deposited on the skin’s surface, which will improve the appearance of a person’s face and neck.
So, whether you’re unhappy with your skin’s appearance or just want to achieve a youthful, glowing look, you should consider trying out a skin tightening treatment. These treatments are non-invasive, easy to use, and can provide you with amazing results.
You can connect with Dr Niketa Sonavane who is a renowned Celebrity Dermatologist, for your skin tightening treatment in Mumbai.
What Are The Best Ways To Prevent Sun Damage On Skin?
The warm weather is finally here, which for most people means it’s time to break out the shorts and tank tops. However, this also means that it’s time to start thinking about how to protect your skin from the sun’s harmful UV rays.
Sun exposure is the number one cause of skin cancer, so it’s important to take steps to prevent it. Many people take care of their skin and use sunscreen when they are outside, but there are other ways to prevent damage to the skin.
One way is to avoid going out in the sun if you can. Another way is to put on layers of clothes to protect your skin from the sun’s harmful rays. Finally, using creams and moisturizers that contain antioxidants will also help your skin stay healthy and protected from the damage caused by excessive sun exposure.
How to choose the best dermatologist for pigmentation treatment
Pigmentation of the skin can be caused by various factors, such as sun exposure, genetics, and hormonal changes. While it is not a life-threatening condition, pigmentation can be unsightly and lead to a loss of self-confidence. There are many factors to consider when choosing a dermatologist for pigmentation treatment.
- Make a list of local dermatologists who specialize in treating pigmentation issues.
- Research each doctor on your list and read reviews from patients who have received treatment for pigmentation issues.
- Ask your friends and family for recommendations.
- It is also important to find a dermatologist who you feel comfortable with and who is willing to take the time to understand your individual concerns.
How does pigmentation removal work?
Pigmentation removal can be a great way to address skin discoloration and make your skin look more uniform. Pigmentation is the result of an excess of melanin, the natural substance that gives color to hair, skin, and eyes. The amount of melanin in your skin can vary from one person to another, with darker-skinned people having more melanin than lighter-skinned people. There are a number of ways to remove pigmentation, including lasers, light therapy, chemical peels, Mesotherapy, PRP skin treatment, and Glutathione Injections.
- The pigmentation in the skin is removed by a laser pigmentation treatment.
- The heat from the laser vaporizes the pigment inside the cells and makes it easier for the skin to naturally clear it up.
- This process can take anywhere from several seconds to 20 minutes, depending on how large it is.
- You may also need several sessions depending on the type of pigmentation and your body’s response to the treatment.
Pigmentation is the natural coloring of skin, hair, and eyes. It can be affected by many factors, such as age, race, and sun exposure. While most people have some pigment in their skin, excessive pigmentation can lead to an uneven complexion and an aged look. Pigmentation removal is a cosmetic procedure that uses lasers or light-based treatments to remove excess pigmentation.
Sun damage can lead to a number of skin problems, including wrinkles and age spots. Fortunately, there are many ways you can prevent sun damage from happening in the first place. Make sure to wear sunscreen every day, choose hats and sunglasses that protect your eyes, and stay out of the sun during peak hours (between 10 am and 2 pm).
You can connect with Dr Niketa Sonavane, Celebrity Dermatologist and founder of Ambrosia Aesthetics for your pigmentation treatment in Mumbai.
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