Cannabis is one of the most widely used illicit drugs in the world. It has been proven beneficial in reducing the symptoms of severe medical conditions, while many scientific studies are being held to understand its recreational effects.
The little that we know about its influences on the brain is from the experiments on animals. It has been confirmed that the primary psychoactive element of cannabis, Delta 9-Tetrahydrocannabinol (known as THC), produces dose-dependent toxicity significant alterations in brain areas deep in cannabinoid CB1 receptors.
CB1 is found in the amygdala, hippocampus, prefrontal cortex, cerebellum, and striatum. Experts then discovered the body’s natural substances—anandamide and 2-arachidonoyl glycerol (2-AG)-which also act on CB receptors. These compounds (named cannabinoids), with their receptors, form the endocannabinoid (EC) system.
Scientists found the EC system in many brain sections, revealing why it impacts so many different body functions.
Does THC Affect The EC System?
Yes, of course. When someone smokes a joint, THC gets into the brain quickly and connects to cannabinoid receptors. The genetic EC system is finely tuned to respond appropriately to incoming data. But the chemical structure of THC is similar to the brain compound anandamide. Due to the similarity in structure, the body accepts THC and changes regular brain communication.
THC enters the system like a sledgehammer, overwhelming the endocannabinoid system with the signs the postsynaptic neurons didn’t send. When presynaptic neurons over the brain get the signal to stop forwarding neurotransmitters, it changes the typical course of information between neurons that ends in a high.
This way, THC overcomes the EC system, blocks the natural substances from doing their work correctly, and drives the whole system off balance.
How Does Marijuana Get You High?
In humans, psychoactive cannabinoids generate euphoria, enhanced sensory perception, antinociception, tachycardia, concentration problems, and memory impairment. The cognitive insufficiencies seem to continue after withdrawal.
As we mentioned above, THC mimics the movements of anandamide, suggesting that THC connects with cannabinoid receptors and stimulates neurons, which produces adverse effects on the mind and body.
High consistencies of cannabinoid receptors exist in the cerebellum, hippocampus, and basal ganglia. The hippocampus lies within the temporal section and is important for short-term memory. When the THC unites with the cannabinoid receptors inside the hippocampus, it conflicts with the memory of recent events.
THC also influences coordination, which the cerebellum controls. The basal ganglia regulate unconscious muscle moves, which is another reason why driving is not allowed under the influence of weed or any other drugs.
The primary effects produced by the THC in cannabis wear off after an hour or two, but the compounds stay in the body for much longer ( as much as 90 days).
Best Marijuana Strains For Long Lasting High
With the acknowledgment of the benefits that marijuana has, the use of cannabis for cerebral relaxation increases. If you want a steady, long-lasting high, you have to pick from Sativa and Indica strains as they work best when you want to be in a state of euphoria for a longer time.
If you’re thinking of smoking marijuana during the day and looking for a strain that will offer a long-lasting high, search for a Sativa strain with over 20% THC. This will be strong enough to keep you loaded for an extended period while still having enough stamina to go about your day.
You should go for Indica strains if you want to burn your stash in the middle of the day or evening. Here also, look for a strain with a high THC ratio for a long-lasting high.
Here are some of the best marijuana strains you should look for if you want to stay blazed for a long time:
Having 26.3% THC, Jack Herer is a must-try for seasoned users who want a punch of energy with the feeling of tranquillity. Jack Herer has an intense aroma with earthy, spicy undertones. Thus, it is an ideal strain for those days when you have a hectic schedule and want an afternoon pick-me-up.
As the name suggests, Purple Punch is a potent Indica strain that produces a strong kick to the mind and body, leaving you in a state of total ecstasy. What starts as a lightheaded sensation quickly flows down through the limbs and sinks deep inside you to help reduce stress, insomnia, and anxiety.
Silver Haze provides a lot of punch at 23 percent THC. Accidentally, it’s the THC where this strain takes its name. It has a generous amount of sparkling THC glands that cover the buds. Giving strong euphoric effects within minutes of use elevates moods and makes users feel very happy. Some users also feel a surge in energy that makes them want to get outside and do something.
With the classic genetics of Girl Scout Cookies and Gelato, this strain is perfect for the users looking for relaxation throughout the high. Loaded with up to 28% THC, it’s pretty much as strong as you can get, producing a quick high that hits from the top down. Those who use cannabis regularly love the cerebral, almost stimulant buzz that comes with a gentle, relaxing feeling.
Being a hybrid strain, with about 25% THC, Bruce Banner hits hard and quick. Smoking this strain will drive your head to generate introspective thoughts as you sense the happiness and good vibes seamlessly elevate your mood. In the meantime, you can literally feel all your tensions vanishing off, followed by a mild buzz that does not induce tiredness but instead keeps you alert and focused.
Along with the strain you choose, the consuming method would also affect the length of your high. A perfect combination of the right strain and method would leave you stoned like never before!
A Word Of Caution!
High-THC cannabis strains are among the most potent marijuana products you can find. While they can be beneficial for treating several health conditions, they also tend to have powerful psychological effects. If you’re new to cannabis, consider beginning with low-THC strains and working your way up. Even if you’re a seasoned smoker, move slow while using high-THC products.