The advanced drug delivery systems (ADDS) market is expected to register a CAGR of 5.3% during the forecast period (2021-2026).
The COVID-19 pandemic is expected to have a significant effect on the market. Several studies emphasized how ADDS will help develop improved delivery systems (dosage forms) of existing therapeutic agents. For instance, in June 2020, Chalmers University of Technology, Sweden, the University of Gothenburg, and AstraZeneca, announced a new pivotal project for investigating a nasal spray mRNA vaccine against COVID-19 by combining several promising concepts. The group currently is exploring design principles for nasal immunization, developing a biomimetic nanoparticle provided with both immune enhancers and a targeting protein. The project is funded by the Chalmers Innovation Office, Chalmers Area of Advance Health Engineering, The Swedish Foundation for Strategic Research, and the Swedish Research Council (VR). In April 2020, Bioavanta-Bosti developed a 48-hour manufacturing process, using its Novochizol chitosan polysaccharide nanotechnology to encapsulate APIs or biologics for localized delivery and sustained release in order to generate intra-pulmonary drug delivery formulations which is suitable for treating COVID-19 patients. In 2020, Bioavanta-Bosti also announced seeking partnerships with drug developers and clinical researchers to rapidly develop a repurposed drug or new molecular or biological entity formulations to help treat severe COVID-19 infection in the lungs. ADDS has helped to explore the new insights to find out the void spaces for a potential targeted delivery and is being rapidly recognized by both the pharmaceutical industry and research institutions.
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The factors that are driving this market includes the development of new drugs and biologics, advancements in understanding human biology and diseases, and increased R&D spending.
Advancements in several biology-oriented initiatives have opened a unique opportunity to better understand the molecular effects of human diseases and develop novel drugs and biologics based on these factors. The recently discovered advanced drug delivery systems include lipid, protein, and polymer technologies with better lipid distribution in the body, preventing drug degradation due to the external environment and reducing the rate of drug clearance. The advanced drugs and biologics have higher efficiency with a smaller dosage of drugs, and hence they have to be supported with advanced drug delivery systems to gain maximum efficacy from the drug. In addition to the drugs and biologics, the drug-eluting implants have the potential to provide uninterrupted treatment and reduction in drug dosage (hence lesser need for frequent dosing). The advanced sustained release systems help target intestinal infections and others. The growing trend toward self-injection devices and the rapidly growing pipeline of biologics/biosimilars and auto-injectors have also recently emerged as an important class of medical devices. Many companies are focusing on the launch of new products that will contribute to market growth. For instance, in July 2019, Mylan announced the launch of its adalimumab biosimilar. Adalimumab is an injectable biologic drug that inhibits Tumor Necrosis Factor (TNF) and is indicated for treating a variety of rheumatic, dermatological, and gastroenterological autoimmune diseases. Also, Similarly, in February 2019, Sandoz, a Novartis division and a global leader in biosimilars, received European Commission approval for adalimumab biosimilar, HYRIMOZ, for subcutaneous injection in either a syringe or prefilled pen in Spain.
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